The Olsen Twins Design $55,000 Backpack

Stylewatch
Style News Now

12/06/2012 at 06:00 PM ET

Courtesy Just One Eye; Inset: Sipa

We’re positive we weren’t the only ones whose jaws dropped when we read that Mary-Kate and Ashley Olsen‘s fashion line, The Row, is selling $55,000 backpacks.

But this isn’t exactly the Jansport you carried your Trapper Keepers in during elementary school. The extravagant accessory is designed in collaboration with renowned artist Damien Hirst and it’s been dubbed “wearable art.” The backpack is limited edition — as in, there are only 12 of these babies. Each bag features black patent, Nile crocodile leather and is adorned with various designs (like pills or gold circles) courtesy Hirst.

Initially the price of the backpack was originally kept hush-hush and The Row declined to release that info. But when we called Just One Eye (the site selling the creations), they shared with PEOPLE.com the five-figure price tag.

But before you go thinking that absolutely no one is going to drop $55,000 on a backpack, consider this: The Olsens released a similar a purse for $39,000 earlier this year — and it sold out. Tell us: If you had all the money in the world, would you buy this backpack? If not, how much would you pay for it?

–Jennifer Cress

PHOTOS: SHOP STAR STYLE — FOR LESS!

Read More..

Celebrations planned as Wash. legalizes marijuana

SEATTLE (AP) — Legal marijuana possession becomes a reality under Washington state law on Thursday, and some people planned to celebrate the new law by breaking it.

Voters in Washington and Colorado last month made those the first states to decriminalize and regulate the recreational use of marijuana. Washington's law takes effect Thursday and allows adults to have up to an ounce of pot — but it bans public use of marijuana, which is punishable by a fine, just like drinking in public.

Nevertheless, some people planned to gather at 12:01 a.m. PST Thursday to smoke in public beneath Seattle's Space Needle. Others planned a midnight party outside the Seattle headquarters of Hempfest, the 21-year-old festival that attracts tens of thousands of pot fans every summer.

"This is a big day because all our lives we've been living under the iron curtain of prohibition," said Hempfest director Vivian McPeak. "The whole world sees that prohibition just took a body blow."

In another sweeping change for Washington, Gov. Chris Gregoire on Wednesday signed into law a measure that legalizes same-sex marriage. The state joins several others that allow gay and lesbian couples to wed.

That law also takes effect Thursday, when gay and lesbian couples can start picking up their wedding certificates and licenses at county auditors' offices. Those offices in King County, the state's largest and home to Seattle, and Thurston County, home to the state capital of Olympia, planned to open the earliest, at 12:01 a.m. Thursday, to start issuing marriage licenses. Because the state has a three-day waiting period, the earliest that weddings can take place is Sunday.

The Seattle Police Department provided this public marijuana use enforcement guidance to its officers via email Wednesday night: "Until further notice, officers shall not take any enforcement action — other than to issue a verbal warning — for a violation of Initiative 502."

Thanks to a 2003 law, marijuana enforcement remains the department's lowest priority. Even before I-502 passed on Nov. 6, police rarely busted people at Hempfest, despite widespread pot use, and the city attorney here doesn't prosecute people for having small amounts of marijuana.

Officers will be advising people to take their weed inside, police spokesman Jonah Spangenthal-Lee wrote on the SPD Blotter. "The police department believes that, under state law, you may responsibly get baked, order some pizzas and enjoy a 'Lord of the Rings' marathon in the privacy of your own home, if you want to."

Washington's new law decriminalizes possession of up to an ounce for those over 21, but for now selling marijuana remains illegal. I-502 gives the state a year to come up with a system of state-licensed growers, processors and retail stores, with the marijuana taxed 25 percent at each stage. Analysts have estimated that a legal pot market could bring Washington hundreds of millions of dollars a year in new tax revenue for schools, health care and basic government functions.

But marijuana remains illegal under federal law. That means federal agents can still arrest people for it, and it's banned from federal properties, including military bases and national parks.

The Justice Department has not said whether it will sue to try to block the regulatory schemes in Washington and Colorado from taking effect.

"The department's responsibility to enforce the Controlled Substances Act remains unchanged," said a statement issued Wednesday by the Seattle U.S. attorney's office. "Neither states nor the executive branch can nullify a statute passed by Congress" — a non-issue, since the measures passed in Washington and Colorado don't "nullify" federal law, which federal agents remain free to enforce.

The legal question is whether the establishment of a regulated marijuana market would "frustrate the purpose" of the federal pot prohibition, and many constitutional law scholars say it very likely would.

That leaves the political question of whether the administration wants to try to block the regulatory system, even though it would remain legal to possess up to an ounce of marijuana.

Colorado's measure, as far as decriminalizing possession goes, is set to take effect by Jan. 5. That state's regulatory scheme is due to be up and running by October 2013.

___(equals)

Johnson can be reached at https://twitter.com/GeneAPseattle

Read More..

L.A. literary stalwart selected as city's first poet laureate

Before sitting down for tea in Echo Park, the poet reaches for her iPhone.

"I have to turn this thing off," she explains, silencing the ringer. "It's getting too noisy these days."

As a publisher, educator and author of seven books of poems, Eloise Klein Healy is a stalwart of the Los Angeles literary scene. Her phone has been buzzing more than usual in recent weeks as she prepares to take on a new title. On Friday, Healy will be named L.A.'s first poet laureate.

Mayor Antonio Villaraigosa decided earlier this year that his city, like others, should have a namesake poet. The mayor, who chose Healy from a pool of three finalists recommended by a selection panel, said he was moved by the grace of her writing and by her "belief in the power of poetry, and her commitment to sharing this power far and wide."

Healy spent her formative years in Iowa and still maintains an air of Midwestern modesty. She says she doubts the quality of her poems won her the laureate honor.

She guesses it had more to do with her long involvement in the arts community, especially the feminist art movement of the 1970s, and her subject matter: Los Angeles looms large in her work.

She writes lovingly of helicopters and bougainvillea, of strip malls and Santa Anas. Car thefts and stabbings are part of the backdrop. Freeways wind freely through her verse.

In a poem called "Los Angeles," Healy describes the city as an older sister who was less pretty and less charming than her younger sibling. "There was something about your proportions / that was indelicate — your more abundant waist," she tells the city.

But in the final verse, a person enters and loves Los Angeles anyway:

Nobody expected it

and you never told about

the lover who met you

loose and large

in the late afternoon

and loved you all night,

completely out of proportion.

Healy says she writes about Los Angeles to understand "the influence of place on people."

It's a technique she employs often. Once, while working on a book of poems about Sappho, the classical lyric poet, Healy traveled to the poet's birthplace on the island of Lesbos in Greece. "I wanted to walk on a beach where she could have walked," Healy said. "I wanted to look at that horizon."

Healy is 69, but she seems much younger. She is trim, with olive skin and snow-white hair. For years, she lived down the street from the small Sunset Boulevard cafe where she sipped tea one morning this week. She chronicled her time in the neighborhood in a book called "Artemis in Echo Park."

Since 1988, she has lived in Sherman Oaks with her partner, Colleen Rooney.

Read More..

Congo Peace Talks Set to Open in Uganda

KAMPALA, Uganda — Congolese rebels and government officials prepared on Thursday for direct peace talks in the Ugandan capital, Kampala, their first face-to-face encounter since the rebels relinquished Goma, one of Congo’s principal cities, after capturing it last month.

“Since May, we asked Kabila to come to the table,” said Amani Kabasha, a spokesman for the March 23 rebels, or M23, at the rebel-held border post of Rumangabo. Mr. Kabasha said his delegation was awaiting vehicles sent by the Ugandan government to carry them to Kampala. “He didn’t agree, he used force, arms, fighting. But now, because he was defeated, he agrees,” Mr. Kabasha said, referring to President Joseph Kabila.

An uneasy rhythm of commerce and calm returned to Goma this week as Congolese government soldiers again patrolled the streets and the port and airport reopened, allowing a fresh influx of people and cargo, as well as much-needed humanitarian aid for more than 100,000 people displaced by the recent fighting.

“It’s as good as it has been for the last two and a half weeks,” Tariq Riebl, a humanitarian coordinator for Oxfam in Goma, said Thursday. But the situation remained “very dynamic, very fluid,” he said.

In the strategic area of Masisi, to the northwest of Goma, fighting has continued to flare between government troops and numerous militias. Masisi has long been a hotbed of militia groups and ethnic tensions, and humanitarian relief workers said they were increasingly worried about the situation.

Furthermore, neither side has said it has any real faith in the upcoming talks, which delegates said would likely begin Friday, or possibly late Thursday.

“It’s not a negotiation,” said a Congolese government spokesman, Lambert Mende. “We will receive a grievance from M23 and help the president compare with what was decided in 2009,” when the peace agreement for which the rebels are named was signed on March 23.

“We are not very optimistic, because we know that M23 is a very small part of the problem; we need the problem to be solved regionally, and internationally,” Mr. Mende said.

The governments of Uganda and Rwanda have denied accusations by a United Nations panel of covertly supporting the M23 rebels, including in the rebels’ capture of Goma. Both countries have been accused of supporting other Congolese rebels groups in the past.

Many of the rebels’ demands, which the government has dismissed, would benefit Rwanda and Uganda, which are two main transit points for commercial exports from eastern Congo.

“We want more than decentralization, we want federalism,” said Mr. Kabasha, although the specific demands had not yet been finalized. “The eastern parts of Congo’s interests are in eastern Africa. Decentralization means that the leader is near the population.”

In recent days there have been reports of lootings and rape, summary executions and recruitment of children, the United Nations office for humanitarian affairs has said. In Goma, there have also been reports of targeted killings.

Read More..

Brooke Burke-Charvet on Cancer Scare: I'm Not Afraid Anymore

TV Watch

Dancing With the Stars

By Tim Nudd

12/06/2012 at 08:40 AM EST

When you're a mom who gets a cancer scare, you're not the only one at home who suddenly needs comfort and support.

In the midst of her thyroid diagnosis Brooke Burke-Charvet – a mother of four – has learned just how vulnerable children can be at such a time, and how differently each one can respond to that kind of stress and anxiety.

"I've really realized that everything I'm going through, my family is going through too," the Dancing with the Stars host, 41, writes in a new blog post.

Burke-Charvet decided initially not to reveal the diagnosis to daughters Neriah, 12, Sierra, 10, and Rain, 5, and son Shaya, 4. "I didn't want them to worry," she writes. "I know that my younger ones still don't have a great concept of time and I didn't want them to be anxious, worried and asking 1,000 questions."

Soon, the kids overheard things, and she and her husband David Charvet told them what was going on. Each child reacted differently, says Burke-Charvet – with emotions ranging from anger to fear to surprise, hope, protectiveness and worry.

The Children React

Shaya's reaction was the most heartbreaking. "He laid in bed last night with David, kinda sad and said, 'I don't want Mommy to die,' " Burke writes. "We both held him and told him that I wasn't going to leave him ever. I know that my surgery is not that serious, but kids get scared, hear 'hospital' and go to the darkest place. Poor little guy."

As she comforted each child in a different way, Burke-Charvet also cared for her husband as he was caring for her.

"He's been so strong and such a rock," she writes. "He's trying not to show any of his fears and concerns so that he can be strong for me. But we've had our moments and I think it's so, so important that you care for everyone in a family that's dealing with a medical crisis the same way you emotionally care for the patient themselves."

As the surgery approaches, she has packed her bag, sorted things out at the house and stocked the fridge with leftovers for the family. Now, she just wants the surgery to be over.

"I'm not afraid anymore," she says. "I think I've been dealing with it so much the past couple months that now I'm ready to just get it done and put this behind me. My only need is being ok for my husband and my children so they don't have to go through any pain and making this as easy as possible for them."

Read More..

Celebrations planned as Wash. legalizes marijuana

SEATTLE (AP) — Legal marijuana possession becomes a reality under Washington state law on Thursday, and some people planned to celebrate the new law by breaking it.

Voters in Washington and Colorado last month made those the first states to decriminalize and regulate the recreational use of marijuana. Washington's law takes effect Thursday and allows adults to have up to an ounce of pot — but it bans public use of marijuana, which is punishable by a fine, just like drinking in public.

Nevertheless, some people planned to gather at 12:01 a.m. PST Thursday to smoke in public beneath Seattle's Space Needle. Others planned a midnight party outside the Seattle headquarters of Hempfest, the 21-year-old festival that attracts tens of thousands of pot fans every summer.

"This is a big day because all our lives we've been living under the iron curtain of prohibition," said Hempfest director Vivian McPeak. "The whole world sees that prohibition just took a body blow."

In another sweeping change for Washington, Gov. Chris Gregoire on Wednesday signed into law a measure that legalizes same-sex marriage. The state joins several others that allow gay and lesbian couples to wed.

That law also takes effect Thursday, when gay and lesbian couples can start picking up their wedding certificates and licenses at county auditors' offices. Those offices in King County, the state's largest and home to Seattle, and Thurston County, home to the state capital of Olympia, planned to open the earliest, at 12:01 a.m. Thursday, to start issuing marriage licenses. Because the state has a three-day waiting period, the earliest that weddings can take place is Sunday.

The Seattle Police Department provided this public marijuana use enforcement guidance to its officers via email Wednesday night: "Until further notice, officers shall not take any enforcement action — other than to issue a verbal warning — for a violation of Initiative 502."

Thanks to a 2003 law, marijuana enforcement remains the department's lowest priority. Even before I-502 passed on Nov. 6, police rarely busted people at Hempfest, despite widespread pot use, and the city attorney here doesn't prosecute people for having small amounts of marijuana.

Officers will be advising people to take their weed inside, police spokesman Jonah Spangenthal-Lee wrote on the SPD Blotter. "The police department believes that, under state law, you may responsibly get baked, order some pizzas and enjoy a 'Lord of the Rings' marathon in the privacy of your own home, if you want to."

Washington's new law decriminalizes possession of up to an ounce for those over 21, but for now selling marijuana remains illegal. I-502 gives the state a year to come up with a system of state-licensed growers, processors and retail stores, with the marijuana taxed 25 percent at each stage. Analysts have estimated that a legal pot market could bring Washington hundreds of millions of dollars a year in new tax revenue for schools, health care and basic government functions.

But marijuana remains illegal under federal law. That means federal agents can still arrest people for it, and it's banned from federal properties, including military bases and national parks.

The Justice Department has not said whether it will sue to try to block the regulatory schemes in Washington and Colorado from taking effect.

"The department's responsibility to enforce the Controlled Substances Act remains unchanged," said a statement issued Wednesday by the Seattle U.S. attorney's office. "Neither states nor the executive branch can nullify a statute passed by Congress" — a non-issue, since the measures passed in Washington and Colorado don't "nullify" federal law, which federal agents remain free to enforce.

The legal question is whether the establishment of a regulated marijuana market would "frustrate the purpose" of the federal pot prohibition, and many constitutional law scholars say it very likely would.

That leaves the political question of whether the administration wants to try to block the regulatory system, even though it would remain legal to possess up to an ounce of marijuana.

Colorado's measure, as far as decriminalizing possession goes, is set to take effect by Jan. 5. That state's regulatory scheme is due to be up and running by October 2013.

___(equals)

Johnson can be reached at https://twitter.com/GeneAPseattle

Read More..

Republican Kevin James makes an outsider run for L.A. mayor

A fundraiser put on by heavyweights in Los Angeles' liberal-leaning environmental community should have been a tough crowd for Kevin James.

But James, affable, polite and the only Republican candidate in a Los Angeles mayor's race dominated by City Hall Democrats, had no trouble chatting up guests as he made his way around the crowded event for the Los Angeles League of Conservation Voters.

Richard Mueller, an executive with a multinational manufacturer, and Dave Alba, his business partner, seemed happy to corner him. The men spent several minutes outlining a massive freight automation project they are hoping to bring to San Pedro — a tough sell in labor-friendly L.A. They were at the party hoping to line up support for the project.

James listened intently, asked questions and took cards from both men before moving on. Afterward, Mueller declared himself impressed. James' candidacy gives the business community hope that private-sector interests will be given real attention in the mayoral race, he said.

"In this city, you have to work both sides — business and labor," Mueller said. "He'd be a win-win."

James, 49, an Oklahoma native with a sharp legal mind, has emerged as the dark horse in a field made up of career politicians. Although the lawyer and talk-show host has never spent a day in the rough and tumble of public office, he says he'll curtail what he characterizes as the cronyism and scandal that dogs City Hall, cut red tape for businesses, foster jobs and demand reductions in public worker pensions to bring stability to the city's chronically underfunded budget.

And he can do that, James insists, because he's the only outsider of the major candidates who will appear on the March primary ballot. The others are Controller Wendy Greuel, previously a city councilwoman, and council members Eric Garcetti and Jan Perry.

If elected, James would make history as the first gay mayor of Los Angeles. He's never tried to hide his homosexuality, he says, but he also does not make an issue of it. He's now a well-regarded litigator in private practice, a former radio talk show host and a longtime activist with AIDS Project Los Angeles who served for a time as its chairman.

In debates and at events, James displays a commanding grasp of city issues. And he seems to be everywhere, shaking hands wherever there might be potential supporters. The GOP establishment has taken note.

Former L.A. County Dist. Atty. Steve Cooley has endorsed James, and a "super PAC" made up of well-connected GOP donors recently formed to independently support his campaign without having to comply with the city's contribution limits. Those moves, political analysts say, have given his run a new legitimacy.

"In the past couple of months he's gone from being an afterthought to a long shot to a plausible outsider candidate," said Dan Schnur, a former Republican strategist and professor at USC's Jesse M. Unruh Institute of Politics.

Friends call him hard-working and passionate about what he thinks should be done to return L.A. to economic vibrancy. Todd Eagan, an attorney who's worked with James for years at Lavely and Singer, an entertainment law firm, said James was the firm's go-to guy when facing a tough legal issue.

"Kevin is the person who can cut through to the main issues and solve the problem," Eagan said. "He has a tremendous grasp of the details of any situation."

Another longtime friend, Steve Reymer, said James has a big heart for animals, adopting a rescue Dachshund, Lisa Marie.

Raised in Norman, Okla., James received an accounting degree from the University of Oklahoma and later moved to Houston to earn a law degree. In college, he registered as a Republican. When he moved to Los Angeles in 1988, he interned at Gibson, Dunn and Crutcher, one of the city's premiere law firms. He also worked for three years as an assistant federal prosecutor in the U.S. attorney's office, handling criminal cases involving drugs, money-laundering and insurance fraud before returning to private practice.

James said that as he became involved in AIDS Project Los Angeles — serving six years on its volunteer board and still serving as an honorary ambassador — he switched his party registration to Democratic because he thought the GOP was too slow to respond to the AIDS health crisis. In later years, as he began to focus more on economic rather than social issues, he said, he again switched his voter registration to decline-to-state.

Craig E. Thompson, executive director of AIDS Project Los Angeles, called him an "effective and well-spoken" board member during his tenure. In board meetings, even when voicing a dissenting point of view, he was always calm and reasonable, Thompson said.

AIDS Project Los Angeles often used James as its official spokesman during those years because he was personable and articulate, Thompson said.

James began filling in as a host on KABC-AM talk radio (790) in 2003 and moved to Oklahoma City the following year to host a morning drive-time show.

In early 2005, he returned to his Laurel Canyon home and registered a third time, back to Republican. The move was prompted by his growing concerns about the economy and his feeling that if he delved more deeply into politics, the GOP would benefit from having more openly gay members in its ranks.

Read More..

India Ink: India's Parliament Opens Door to Foreign Retail Investors

After two days of sometimes ear-splitting debate, India’s Lok Sabha, or lower house, of Parliament voted down a measure prohibiting large foreign retailers like Wal-Mart from entering the country. Of the 543 members in the house, 218 voted in favor of a proposition banning these companies from the country, and 253 against.

Rival leaders from Uttar Pradesh, Samajwadi Party leader Mulayam Singh Yadav and Bahujan Samaj Party leader Mayawati, walked out before the debate and their parties’ abstentions helped defeat the measure.

The issue will now travel to the upper house of Parliament.

Allowing foreign multi-brand retailers into India has been a matter of debate for years, and was fast-tracked this year by a government under fire from allegations of corruption and paralysis. Here’s recent India Ink coverage on the issue:

The United Progressive Alliance government announced in September that they would allow big department stores who carry multiple brands, like Wal-Mart Stores, into the country but “laid out some very specific conditions,” Heather Timmons reported.

In an interview with India Ink in the same month, Anand Sharma, the minister of commerce and industry, said that despite the conditions some companies had “already expressed interest, from Tesco to Carrefore to Wal-Mart and Marks and Spencer.”

Explaining the benefits for rural producers he said:

“It will benefit the rural economy with the farmers, who will get a better price for what they produce. What perishes to a large extent will reach the market or the kitchens.”

The announcement was met with skepticism from industry and analysts, Vikas Bajaj reported, but there was hope that “If they follow through, it could prompt a new economic boom in India, where once-brisk growth has slowed markedly in recent years. But it is a big if.”

In a later article he focused on the way foreign direct investment in retail “often divides Indians as much by age as by their livelihoods.”

“Those younger than 25, a group that includes about half the country’s 1.2 billion people, appear quite open and eager to try foreign brands and shopping experiences, researchers say,” Mr. Bajaj wrote.

The Prime Minister, in a rare address to the nation, tried to assuage small retailers’s fears in late September, by saying that they “had nothing to fear from the impending arrival of giant Western retailers like Wal-Mart or Carrefour because there was a place for everyone, large or small, in a growing economy.”

The government may be overly optimistic about the benefits of allowing foreign direct investment into the retail sector, judging by Wal-Mart’s experience in other countries.

And even if that is not true, “any long-term impacts of Wal-Mart’s Mexico business have been overshadowed this year by the company’s involvement in a bribery scandal there,” and was “sure to find similar demands for bribes in India – especially now that ample evidence exists that the company has paid them elsewhere,” Heather Timmons wrote in an article titled, “Can Wal-Mart Build a Nation?”

In November, Wal-Mart said that an internal “investigation into violations of a federal anti-bribery law had extended beyond Mexico to China, India and Brazil, some of the retailer’s most important international markets,” Stephanie Clifford and David Barstow wrote in the New York Times.

Read More..

John Krasinski: I'm 'Totally in Love' with Matt Damon

By Paul Chi

12/05/2012 at 08:55 AM EST

John Krasinski and Matt Damon at the Promised Land premiere in N.Y.C.

Andrew H. Walker/WireImage

Move over, Ben Affleck! John Krasinski wants to be Matt Damon's new best friend.

"Matt is one of the coolest guys I know, and I'm totally in love with the guy, but he doesn't even know my name," Krasinski joked to PEOPLE at the New York premiere of his new movie Promised Land on Tuesday.

"I would love to have a bromance with him," he continues, "but I don't even know if I could even use the word 'bromance' because he and Ben are so tight and like a married couple that I'll never get in there."

The Office star, 33, first met Damon through his wife Emily Blunt when she starred in 2011's The Adjustment Bureau with him.

Soon, he got the opportunity to work with Damon himself in Promised Land (out in theaters Dec. 28), a new film the pair wrote and star in together. Although Krasinski spent multiple weekends at Damon's house to write the script, he is not satisfied with their strictly working relationship.

"I must be the bromance mistress," he said. "I'm on the outside of the relationship, only working with him on the side while really he's suppose to be with Ben. I'm clearly the mistress and this has got to change!"

Read More..

Longer tamoxifen use cuts breast cancer deaths

Breast cancer patients taking the drug tamoxifen can cut their chances of having the disease come back or kill them if they stay on the pills for 10 years instead of five years as doctors recommend now, a major study finds.

The results could change treatment, especially for younger women. The findings are a surprise because earlier research suggested that taking the hormone-blocking drug for longer than five years didn't help and might even be harmful.

In the new study, researchers found that women who took tamoxifen for 10 years lowered their risk of a recurrence by 25 percent and of dying of breast cancer by 29 percent compared to those who took the pills for just five years.

In absolute terms, continuing on tamoxifen kept three additional women out of every 100 from dying of breast cancer within five to 14 years from when their disease was diagnosed. When added to the benefit from the first five years of use, a decade of tamoxifen can cut breast cancer mortality in half during the second decade after diagnosis, researchers estimate.

Some women balk at taking a preventive drug for so long, but for those at high risk of a recurrence, "this will be a convincer that they should continue," said Dr. Peter Ravdin, director of the breast cancer program at the UT Health Science Center in San Antonio.

He reviewed results of the study, which was being presented Wednesday at a breast cancer conference in San Antonio and published by the British medical journal Lancet.

About 50,000 of the roughly 230,000 new cases of breast cancer in the United States each year occur in women before menopause. Most breast cancers are fueled by estrogen, and hormone blockers are known to cut the risk of recurrence in such cases.

Tamoxifen long was the top choice, but newer drugs called aromatase inhibitors — sold as Arimidex, Femara, Aromasin and in generic form — do the job with less risk of causing uterine cancer and other problems.

But the newer drugs don't work well before menopause. Even some women past menopause choose tamoxifen over the newer drugs, which cost more and have different side effects such as joint pain, bone loss and sexual problems.

The new study aimed to see whether over a very long time, longer treatment with tamoxifen could help.

Dr. Christina Davies of the University of Oxford in England and other researchers assigned 6,846 women who already had taken tamoxifen for five years to either stay on it or take dummy pills for another five years.

Researchers saw little difference in the groups five to nine years after diagnosis. But beyond that time, 15 percent of women who had stopped taking tamoxifen after five years had died of breast cancer versus 12 percent of those who took it for 10 years. Cancer had returned in 25 percent of women on the shorter treatment versus 21 percent of those treated longer.

Tamoxifen had some troubling side effects: Longer use nearly doubled the risk of endometrial cancer. But it rarely proved fatal, and there was no increased risk among premenopausal women in the study — the very group tamoxifen helps most.

"Overall the benefits of extended tamoxifen seemed to outweigh the risks substantially," Dr. Trevor Powles of the Cancer Centre London wrote in an editorial published with the study.

The study was sponsored by cancer research organizations in Britain and Europe, the United States Army, and AstraZeneca PLC, which makes Nolvadex, a brand of tamoxifen, which also is sold as a generic for 10 to 50 cents a day. Brand-name versions of the newer hormone blockers, aromatase inhibitors, are $300 or more per month, but generics are available for much less.

The results pose a quandary for breast cancer patients past menopause and those who become menopausal because of their treatment — the vast majority of cases. Previous studies found that starting on one of the newer hormone blockers led to fewer relapses than initial treatment with tamoxifen did.

Another study found that switching to one of the new drugs after five years of tamoxifen cut the risk of breast cancer recurrence nearly in half — more than what was seen in the new study of 10 years of tamoxifen.

"For postmenopausal women, the data still remain much stronger at this point for a switch to an aromatase inhibitor," said that study's leader, Dr. Paul Goss of Massachusetts General Hospital. He has been a paid speaker for a company that makes one of those drugs.

Women in his study have not been followed long enough to see whether switching cuts deaths from breast cancer, as 10 years of tamoxifen did. Results are expected in about a year.

The cancer conference is sponsored by the American Association for Cancer Research, Baylor College of Medicine and the UT Health Science Center.

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

Read More..